Відео

ua-cam.com/video/iCe8EwY3vsA/v-deo.htmlsi=fIPPllnQrX9y3CbS

**Chapter 1: Introduction and Background** [00:00:03][^1^][1] - Dr. John Leonard's legacy at the University of Washington - Dr. Joel Finkelstein's contributions to bone physiology and male reproductive endocrinology **Chapter 2: Androgens and Estrogens in Men** [00:03:06][^2^][2] - The role of testosterone and estrogen in male physiology - Defining male hypogonadism and its clinical implications **Chapter 3: The Impact of Hormones on Male Physiology** [00:08:01][^3^][3] - The physiological effects of varying testosterone levels - The HIM study: objectives and methodology **Chapter 4: Study Results and Clinical Implications** [00:20:02][^4^][4] - Findings on body composition, bone homeostasis, and sexual function - The importance of estrogen in men's health **Chapter 5: Testosterone Use and Public Health Concerns** [00:46:33][^5^][5] - The debate over testosterone therapy and cardiovascular risks - The need for long-term clinical trials to assess safety **Chapter 6: Future Directions in Hormone Research** [00:52:41][^6^][6] - Potential benefits of estrogen therapy in men with prostate cancer - Closing remarks and Q&A session These chapters provide a structured overview of the video's content, highlighting key topics and findings discussed by Dr. Joel Finkelstein. Each chapter corresponds to a specific segment of the video, allowing viewers to navigate to areas of interest easily.

You are nauseated with metformin and don't have appetite, got severe diarrhea as the bowel moves so fast you don't have time for proper digestion and absorption! Glucose stimulates AMPK and doesn't block the electron transport complex of the mitochondria. Metformin however blocks the first electron transport complex and everything backs up!!! Professor Ben Bikman demonstrated that metformin inhibits the beneficial effect of exercise in promoting mitochondrial growth and development. How can metformin increase insulin sensitivity? Metformin improves A1c by o. 5 only. Laymen just can't see the problem.

Tremendous to have the opportunity to listen to lectures like this. Brilliant man , exciting research and so wonderful that his interest in biochemistry is linked to a fascination with anthropology and human evolution ⭐️

TBI due to car accident in Jan 2020, almost 4 years of never ending symptoms, 3 hospital visits for adrenal crisis (they did not recognize it) only diagnosed in November, and started on HC. I’m curious how to proceed to find out for sure that it was caused by the TBI? So far, I’ve had very little success in finding out pretty well anything about why, or have any further testing. I’ve now lost over 30 lbs in 2 months, intolerance to any sugar, and symptoms are coming back, after a few months of feeling very good.

😢Icthyousis vulgaris scales can be removed

Funny, until recently I hadn't realized that Mario updated his favorite way to tackle ED and it's a relief! Although what he previously suggested was pretty good, it was a real pain to follow... I just go'ogled the latest by Mario Volpstein, it's so much easier and potent now!

Is keto better for gout patients

Why are you wearing a mask all alone in a room? Weirdo.

Best HRS presentation I've seen. Strong work!

very helpful

the very first time I started seeing testimonies about you Dr Abiola, I had that full confidence in you that I even purchased your medicine, my HIV test was tested negative, now I'm so happy that I could finally say thank you so much #DRABIOLA for your hard work care & encouragement you really are a God sent and i appreciate you …

I’m from Malaysia. My brother (age 56) worked in mining industry and was infected with Medioidosis for the past 11 days and is now in ICU, in very critical condition. He has went thru kidney dialysis and show some improvement. He undergo IV treatment. Any advice?

Really a perplexing group of diseases as the PCTL's are split into many subgroups.The only 2 of these disorders i have encountered are PCTL NOS and Mycosis Fungoides.

I agree. We are different. All of us are not the same. We must take this into consideration in our health. This is reality .

This is extremely good news for treating anti-biotic resistant bacterial infections. We need to go all in on developing these phage treatments in the USA.

The video discusses research by Dr. John Dick on normal and cancerous hematopoietic stem cells. Some key points and conclusions: - Hematopoietic stem cells (HSCs) are rare cells that give rise to all blood and immune cells. Studying them in humans is challenging, so Dr. Dick's lab developed a mouse model to assay human HSC function. Using this, they identified the cell surface markers for long-term repopulating HSCs, which can regenerate blood lineages for the life of the mouse. - Single HSCs showed heterogeneity in properties like cell cycle and self-renewal potential. Computationally analyzing gene expression data revealed subpopulations of HSCs with distinct molecular signatures, suggesting there are functional differences even within this rare subset. - The talk highlighted approaches to leverage HSC assays and genomics to improve outcomes in clinical settings like bone marrow transplantation. For example, analyzing HSC content in patient samples identified differences between good and poor graft function after transplant. This demonstrates the potential of advanced HSC profiling to guide treatment decisions. - Inflammation emerged as an important regulator of HSCs. Acute inflammation caused transient HSC activation, while repeated inflammation led to long-term dysfunction, imprinting a type of "memory" on the cells. The concept of an inflammatory memory HSC (HSC2) was introduced. - Further analyses of young vs aged HSCs, T cell memory, COVID-19 survivors, and clonal hematopoiesis models provided evidence that inflammatory memory increases in aging and disease states. This may relate to cumulative inflammatory exposures over time. - Comparison of HSCs with and without leukemia-associated mutations revealed both mutated and normal HSCs have higher inflammatory memory in clonal hematopoiesis, suggesting cross-talk within the system. Inflammation-related changes in normal HSCs may set the stage for and cooperate with mutations. - The possible role of inflammatory memory HSCs was discussed in heart disease, organ transplantation, and other aging conditions. This represents a new dimension to explore alongside genetics in age-related diseases. In summary, Dr. Dick presented his pioneering work dissecting the heterogeneity of HSCs using advanced genomic tools. Key concepts emerging from the research are: - HSCs show functional diversity in self-renewal potential, activation state, and other properties, even within defined surface marker subsets. This challenges the view of HSCs as a homogeneous population. - Inflammatory exposures imprint a type of memory on HSCs through epigenetic reprogramming, leading to lasting changes in function. This may accumulate over a lifetime of inflammation. - Inflammatory memory in HSCs correlates with aging, clonal hematopoiesis, and certain diseases, representing a new mechanism linking inflammation with age-related decline. - Both mutated and normal HSCs exhibit inflammatory memory in clonal hematopoiesis models, implying cross-talk where dysfunctional HSCs promote further dysfunction. - Understanding HSC heterogeneity and the drivers of dysfunction, like inflammatory memory, may open new therapeutic avenues to improve transplantation, prevent clonal hematopoiesis, and combat diseases of aging. The state-of-the-art techniques for isolating and analyzing rare cell populations presented by Dr. Dick are enabling remarkable insights into HSC biology with broad relevance from blood cancers to aging. His work represents the power of combining specialized cell assays with genomic profiling to elucidate mechanisms and clinically-relevant subpopulations among rare, hard-to-study cell types. The proposed links between inflammation, epigenetic memory, clonal hematopoiesis, and onset of age-related diseases in otherwise healthy HSCs reveal intriguing new directions to explore in the quest to understand, detect, and prevent human disease.

The video discusses the recent change in nomenclature from non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction associated steatotic liver disease (MASLD or "mazzled"). The main points are: - The name change from NAFLD to MASLD resulted from a multi-year, multi-society consensus process involving professional societies, patient advocacy groups, and other stakeholders. This was not a rushed or arbitrary change. - There were several factors driving the change, including history, societal pressures to destigmatize the condition, and an improved scientific understanding of the biology and pathogenesis of fatty liver disease. - Historically, fatty liver conditions have been recognized since the 1800s, with terms like "fatty liver" and "non-alcoholic steatohepatitis" (NASH) emerging over time. The term NAFLD was coined in 1980. Recently, there has been more focus on updating the terminology to better reflect current knowledge. - The term NAFLD was stigmatizing to patients - the inclusion of "fatty" and the reference to "alcohol" led to patient shame and discrimination, even for those without advanced disease. Patient advocacy groups pushed for a change to reduce stigma. - Scientifically, there is now more evidence that the pathogenesis is driven by metabolic dysfunction and steatosis (fat accumulation), rather than inflammation. Genetic studies also point to steatosis being the key driver. This led to calls for a more biologically-accurate name. - In 2020, some societies proposed changing the name to "metabolic dysfunction-associated fatty liver disease" (MAFLD). But this was controversial, as societies worldwide were not included in that process. - In response, a formal Delphi consensus process was undertaken from 2020-2022 to re-examine the terminology. This involved societies from around the world, covering hepatology, endocrinology, pediatrics, and many other disciplines. - The Delphi process considered many factors, including the potential impact on patients, clinical practice, trials, and drug development. Extensive discussion and debate occurred over 2 years. - In June 2022, the new term MASLD was announced as the consensus recommendation, referring to “metabolic dysfunction associated steatotic liver disease”. Key features of MASLD: - It applies to all forms of fatty liver disease that are associated with metabolic dysfunction, after excluding other potential causes. This includes obesity, diabetes, hypertension, and lipid disorders. - Specific diagnostic criteria are provided for both adults and children when defining “metabolic dysfunction”. - The term “steatotic” focuses attention on fat accumulation as the key underlying pathology. This is based on an improved scientific understanding of how steatosis drives disease progression. - Use of “metabolic dysfunction” also highlights the metabolic underpinnings versus a primary inflammatory disease. - Alcohol-related liver disease and other specific forms of fatty liver retain their distinct names and are not called MASLD. - For patients with both metabolic dysfunction and excess alcohol intake, the term “metabolic and alcohol-associated steatotic liver disease” (MALD) is used. The goals of the new nomenclature include reducing stigma for patients, better reflecting current science, and providing an impetus for further research and education on fatty liver disease. However, there are still challenges with the transition: - The long name is cumbersome. Shorthand versions like “metabolic liver disease” may be needed for practical use. - Despite attempts to reduce stigma, the words “fatty” and “steatotic” may still carry negative connotations in some sociocultural contexts. - Updating medical coding, medical education, and clinical systems like Epic will take years. NAFLD will likely persist in documents and systems for some time. - Measuring the impact on stigma will require further study. Surveys on patient perceptions should be repeated in the MASLD era. In summary, the name change to MASLD was a deliberate, consultative process by the hepatology community to address the limitations of the prior NAFLD terminology. Work is now needed locally and globally to drive adoption of MASLD and assess its impact. Widespread use of the new nomenclature will likely take years. Patience and collaboration across specialties and systems will be required to ensure this major terminology change achieves its goals.

what is the treatment sir

I got tired with introduction.... better had edit on video...annoying ears

TY. I will go to your clinic.

PLEASE HELP ME!

its interesting to me how Diet is never looked into as a possibility as an asthma trigger

very insightful webinar. thank you, Dr. Mayer, thank you for sharing your insights into the gut microbiome. this augments what I read in your book . I learned so much from reading your book. thank you, Reimara.

💎💎

is there another video with better AUDIO ?

So you want black patients to be only treated by black doctors and white patients to be cared for by only white doctors instead of decreasing implicit bias in both patients and doctors so patients feel comfortable with all physicians regardless of skin color? Knock yourselves out!

I Will forever be grateful to Dr Omole on UA-cam who cured my Genital Herpes virus with his herbs remedy. I will forever tell the world about your great medication doc..

🙋 P r o m o S M

There is nothing wrong with a high fat diet, of course. Try looking at High Fructose corn syrup & seed oils for the culprits in making people fat.

Was this newly discovered disease discovered by the CDC?

Hallway is better because these health care providers don't know how to talk in a culturally sensitive way and will br insulting the patient because of their illness.

What is going on with these diseases Lupus , sjorgens rheumatoid arthritis and autoantibodies? I don’t know, but I do know what William Osler said “ the person who takes medicine must recover twice . Once from the disease and once from the medicine . “ nice that medicine is looking at these antibodies but do a little search for keto and remission of lupus,sjorgens, rheumatoid arthritis and you’ll see some amazing stories , perhaps it’s the bodies reaction to glyphosate causing the antibody response , or the modern processing of wheat ? Or the GMO foods like soy, corn etc. and the fact soy, wheat and sugar is added to foods the government deems fit for human consumption. I usd to think one day science would catch up on the all disease begins in the gut ,I now know science doesn’t want to catch up there’s not the money for research in food and gut health . Currently reading post from 64yo off all meds since 2001, lupus and 4 autoimmune disease in remission, mostly meat and a few carbs . Antibiotics destroy the gut microbiome , whilst needed occasionally over prescription whilst a boon for pharmaceutical companies not so great for the rest of the world . Wish someone with your passion and knowledge could switch lanes and learn functional medicine

This is great and I'm so happy it's being looked into. I have this disease and it would be GREAT if yall would just STOP ✋️ 🫸 saying we do this to ourselves 🛑🤮 They pop up and happen without me doing ANYTHING to my skin. I will not touch them and they STILL appear, with hard painful lumps, then. Red dot, then a crusty sore. Then a huge nodule that never ever goes away and prob will make some new ones along the way. Mine don't itch. They HURT. I need pain medicine become I'm so tired of the chronic pain 😢

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Sir thank you very much for giving so much great information. it gives new dimension to think the subject.🤝

Had you used a proper microphone then this might have been of use.

Thank you so much, this information helps me understand better what's going on with my body, very useful information.

God bless you now and always Dr Igudia on youtube , Just wanted to say a big THANK YOU for helping me cure my Hepatitis B virus I was facing, I am now Hepatitis B negative after my test result came out, I will be happy to recommend you to other people around the word.

Thank you for never letting me down doc. being recommended to doctor Igudia on UA-cam has being a great blessing to my family his cure for type 2 diabetes’s is a genuine one thanks for your good deed toward humanity

Thank you for never letting me down doc. being recommended to doctor Igudia on UA-cam has being a great blessing to my family his cure for type 2 diabetes is a genuine one thanks for your good deed toward humanity.

Thanks for this well researched and thoughtful lecture.

The type of melanin in your genetics plays a major role in the type of nutrition you should be consuming. This is what they who profit from medical treatments will not address. Here's a simple example of our differences; we all know our skin is our largest organ. Black skin needs different nutrients than white skin. Thus Black skin synthesizes uv rays differently than white skin. Same goes for hair. Eumelaninated people's with kinky hair need different nutrients than Pheomelaninated or non melaninated people for hair care. Knowing this why can't we deduce our foods need to be different? Celiac disease is a gluten intolerance that affects Europeans traditionally. Sickle cell anemia is more prevalent in black people. These are both autoimmune diseases driven by genetic differences that can be controlled with food as medicine. Gulo gene and LCT genes are different in many Eumelanin people's vs pheomelanin and mon melaninated people's. Many whites have a LCT gene mutation that causes that gene to stay active after weaning years. This causes a higher metabolism that allow them to be lactase persisters that can continue to drink milk after weaning. Most of the rest of us are lactose intolerant which is the norm for all mammals that feed on their mothers milk. I could go on but this long comment would be a book.

Thanks you Dr Igudia on UA-cam for all you do in my life and my family. I went for a test today after taking the medication i ordered from Dr Igudia and I tested Type 2 Diabetes’s negative. Thanks doctor I will keep letting the world know about your good work sir.

Does anyone know if fever is a sign of infection after pacemaker surgery?

Hi, keep up the work. From what you said, I think you might be interested in this channel 👉 #drjohnaking. I find him instructional and practical.

Your audio make this unusable

I developed central diabetes insipidus permanently ,took 4 yrs for dx. Almost died in 2009. Permanent risk of death coma

☺️ ρяσмσѕм

B.S. the medical authorities and big pharma don't want to cure anything. Too much money in being sick. They dont care.